For the treatment of vitamin B6-dependent disorders such as neuritis, hyperhomocysteinemia
Vitamin B6 is involved primarily in the metabolism of protein and the breakdown of homocysteine, together with vitamin B12 and folic acid. Vitamin B6 deficiency is usually coupled with a deficiency in other vitamins.
Typical signs of vitamin B6 deficiency are:
• nausea, loss of appetite, vomiting
• inflammatory, flaky skin conditions (dermatitis) especially around the nose and eyes
• inflammation in the mouth and on the lips
• insomnia, nervousness, irritability
• nerve disorders
• anemia that does not respond to iron
Changes in the blood due to vitamin B6 deficiency may include an increase in the CRP (C-reactive protein) value as an indication of an immune system disorder and an associated increase in the risk of cardiovascular disease, as well as an increase in the harmful amino acid homocysteine in the blood.
Calcium hydrogenphosphate dihydrate, microcrystalline cellulose, magnesium stearate, corn starch, highly disperse silicon dioxide.
Dosage | ||
---|---|---|
Adults | Behandlung einer peripheren Neuropathie | 50 mg bis 300 mg Pyridoxinhydrochlorid |
Behandlung von pyridoxinabhängigen Störungen | 10 mg bis 250 mg, in Einzelfällen bis 600 mg und mehr Pyridoxinhydrochlorid | |
Behandlung von pyridoxinabhängigen Störungen (Sideroblastische Anämie) | ab 200 mg Pyridoxinhydrochlorid pro Tag empfohlen | |
Children | Behandlung einer peripheren Neuropathie | 50 mg bis 200 mg Pyridoxinhydrochlorid |
Behandlung von pyridoxinabhängigen Störungen | 2 mg bis 200 mg | |
Behandlung von pyridoxinabhängigen Störungen (Sideroblastische Anämie) | 10 mg bis 250 mg Pyridoxinhydrochlorid pro Tag empfohlen |
Adults: Treatment of peripheral neuropathy (neuritis) secondary to drug-induced vitamin B6 deficiency (e.g., caused by medications with active substances such as isoniazid, D-penicillamine, cycloserine).
− Treatment of pyridoxine-dependent disorders (rare metabolic disorders such as primary hyperoxaluria type I, homocystinuria, cystathioninuria, xanthurenic aciduria or rare blood formation disorders such as sideroblastic anemia, hypochromic microcytic anemia caused by vitamin B6 deficiency which can be treated in part with higher vitamin B6 doses).
Children: Treatment of peripheral neuropathy (neuritis) secondary to drug-induced vitamin B6 deficiency (e.g., caused by medications with active substances such as isoniazid, D-penicillamine, cycloserine).
− Maintenance therapy following seizures caused by vitamin B6 deficiency in newborns and infants.
− Treatment of pyridoxine-dependent disorders in children over 1 year of age (rare metabolic disorders such as primary hyperoxaluria type I, homocystinuria, cystathioninuria, xanthurenic aciduria or rare blood formation disorders such as sideroblastic anemia, hypochromic microcytic anemia caused by vitamin B6 deficiency which can be treated in part with higher vitamin B6 doses).
Do not take Vitamin B6-Hevert Tablets if you have an allergy to pyridoxine hydrochloride (vitamin B6) or any of other ingredients.
In patients taking daily doses above 50 mg vitamin B6 as well as short-term use of doses in the one gram range peripheral sensory neuropathy has been observed (nerve disorder with tingling and a pins-and-needles sensation) (see also under Precautions for use). Photosensitivity (hypersensitivity to sunlight) has been described with very high daily doses. Gastrointestinal disturbances have been reported at higher doses.
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