Homeopathy Research: State of the Science - Part 2

Experimental Research on Homeopathy’s Mechanism of Action

1 Experimental research on the similarity principle

The best known current work concerning scientific evidence of the similarity principle stems from two researchers, Roeland van Wijk and Fred A. C. Wiegant. They examined the recovery process of cell cultures that were previously exposed to different cell toxins (arsenic and cadmium) or damaging heat. Their primary focus was to measure the concentrations of stress proteins produced by cells as a response to damage. Wijk and Wiegant were able to show that previously damaged cell systems recover faster when they are confronted again with the harmful substance in an attenuated form, either slightly reheated or treated with diluted arsenic or cadmium. These experiments provide the first indications of how the similarity principle can be preclinically investigated on the cellular level and physiologically understood.

2 Experimental research on potentized remedies

Physical experimental methods

In recent decades, numerous experiments have been conducted to decode homeopathy’s physical mechanism of action. High potency medicines were compared with placebo using mainly standard spectroscopic methods to draw conclusions about physical differences. Significant results that were obtained with Raman and NMR spectroscopy (research methods that examine molecular structure through the means of stimulation by laser light or magnetism) were successfully reproduced. The meta-study by Witt (2006) provides a detailed overview of the different experimental physical studies.

Research on living organisms

Likewise, statistically significant results with regard to the effect of high potency remedies were obtained with test systems that work with plant, animal and cell systems. In this case, the focus is less on how the drug works and more on whether it is possible to prove significant effects. Research teams led by Dr. Peter Christian Endler and PD Dr. Stephan Baumgartner have presented especially promising results.

Endler’s research primarily focuses on tadpoles, which are randomized (assigned randomly) to different groups and then treated differently in a blind approach—the investigator does not know which group is receiving the drug and which the placebo. This amphibian model is based on the influence on the development of the tadpole into a frog by treatment with the thyroid hormone thyroxine, which accelerates the rate of transformation. Endler has conducted numerous trials, including trials with potentized thyroxine compared to placebo to impact the speed of metamorphosis. In another series of tests, all the tadpoles were pretreated first with slightly diluted thyroxine and subsequently further treated with either placebo or potentized thyroxine. The aim of the research was to determine whether the administration of homeopathically prepared thyroxine cancels the accelerated transformation through non-potentized thyroxine. Endler‘s team was able to show that the tadpoles treated with the homeopathic high potency hormone actually developed more slowly than those treated with placebo.

The research group led by the physicist Baumgartner also expended great efforts on experimental research. Their focus is on ultra-high dilutions: on the one hand in physical studies, on the other, their effects on in-vivo test systems. Very plausible results that support the impact of highly potentized homeopathic preparations were obtained with a test system consisting of duckweed cultures, a standard system in ecotoxicology (research on environmental toxins). Since then, several experiments have been carried out with this test system, such as the measurement of the influence of potentized plant hormones (gibberellins) on the growth of duckweed. Likewise, an attempt was made to treat duckweed deficient in calcium, iron or magnesium with potentized remedies. In the case of calcium deficiency, clear effects of homeopathic potencies on plant growth are observed.

The results published in 2009 by Bellavite also support the impact of homeopathic high potencies. This involved an experiment in which the activity of mice was tested. Mice that were treated with gelsemium showed significantly more active behavior towards placebo-treated mice.


  • Atmanspacher H, Römer H, Walach H: Weak Quantum Theory: Complementarity and Entanglement in Physics and Beyond. Foundations of Physics 2002;32:379-406
  • Barnard GP, Stephenson JH: Microdose paradox: A new biophysical concept. Journal of the American Institute of Homeopathy 1967;60:277-86
  • Bellavite P, Magnani P, Marzotto M, Conforti A: Assays of homeopathic remedies in rodent behavioural and psychopathological models. Homeopathy 2009;98:208-27
  • Chikramane PS, Suresh AK, Bellare JR and Kane SG: Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective. Homeopathy 2010;99:231-42
  • Deutscher Zentralverein homöopathischer Ärzte: Studienübersicht. Ein Reader zur Homöopathieforschung. retrieved on 08/27/2013].
  • Endler PC, Lüdtke R, Heckmann C, Zausner C, Lassnig H, Scherer-Pongratz W, Haidvogl M, Frass M: Pretreatment with thyroxin (10-8 parts by weight) enhances a "curative" effect of homeopathically prepared thyroxin (10-13) on lowland frogs. Research on Complementary Medicine / Forschende Komplementärmedizin 2003;10:137-42
  • Graunke H, Endler PC, Scherer-Pongratz W, Frass M, Lothaller H: Treatment of Lowland Frogs from the Spawn Stage on with Homeopathically Prepared Thyroxin (10-30). The Scientific World Journal 2007;7:1697-702
  • Jacobs J, Jonas WB, Jimenez-Perez M, Crothers D: Homeopathy for childhood diarrhea: combined results and metaanalysis from three randomized, controlled clinical trials. Pediatr Infect Dis J 2003;22(3):229-234.
  • Jäger T, Scherr C, Simon M, Heusser P, and Baumgartner S: Effects of homeopathic arsenicum album, nosode, and gibberellic acid preparations on the growth rate of arsenic-impaired duckweed (Lemna gibba L.). ScientificWorldJournal 2010;10:2112-29
  • Jäger T, Scherr C, Simon M, Heusser P, and Baumgartner S: Development of a Test System for Homeopathic Preparations Using Impaired Duckweed (Lemna gibba L.). J Altern Complement Med 2011;17:315-23
  • Karl und Veronica Carstens-Stiftung. Homöopathie – Zum Stand der klinischen Forschung. Stand: März 2006. [retrieved on 11/22/2013]
  • Lenger K: Homeopathic potencies identified by a new magnetic resonance method. Homeopathy – An Energetic Medicine. Subtle Energies & Energy Medicine 2006;15:225-44
  • Lenger K, Bajpai RP, Drexel M: Delayed luminescence of high homeopathic potencies on sugar globuli. Homeopathy 2008;97:134-40
  • Lenger K: A new biochemical model of homeopathic efficacy in patients with different diseases. Subtle Energies & Energy medicine 2010;19:1-34
  • Lingg G, Endler PC, Frass M, Lothaller H: Treatment of Highland Frogs from the Two Legged Stage with Homeopathically Prepared Thyroxin (10-11 – 10-21). The Scientific World Journal 2008;446-50
  • Lüdtke R, Wiesenauer M: A meta-analysis of homeopathic treatment of pollinosis with Galphimia glauca. Wien Med Wochenschr 1997; 147 (14):323-7.
  • Scherr C, Simon M, Spranger J, and Baumgartner S: Effects of potentised substances on growth rate of the water plant Lemna gibba L. Complementary Therapies in Medicine 2009;17:63–70
  • Taylor MA, Reilly D, Llewellyn-Jones RH, McSharry C, Aitchison TC: Randomised controlled trials of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series. BMJ 2000;321:471-476.
  • Upadhyay RP, Nayak C: Homeopathy emerging as nanomedicine. Int J High Dilution Res 2011;10:299-310
  • Welles SU, Endler PC, Scherer-Pongratz W, Suanjak-Traidl E, Weber S, Spranger H, Frass M, Lothaller H: Pretreatment with Thyroxin (10-8 M) and the Effect of Homeopathically Prepared Thyroxin 10e-30 on Highland Frogs - Results of a Multi-Researcher Study. Research on Complementary Medicine / Forschende Komplementärmedizin 2007;14:353-7
  • Wijk van R, Wiegand FAC: The Similia Principle. An Experimental Approach on the Cornerstone of Homeopathy. Essen: KVC Verlag, 2006
  • Witt CM, Lüdtke R, Baur R, Willich SN: Homeopathic medical practice: Long-term results of a cohort study with 3981 patients. BMC Public Health 2005;5:115.
  • Witt C. Physikalische Untersuchung homöopathischer Hochpotenzen. 1. Nachdruck. Essen: KVC Verlag, 2006
  • Wolf U, Wolf M, Heusser P, Thurneysen A, and Baumgartner S: Homeopathic Preparations of Quartz, Sulfur and Copper Sulfate Assessed by UV-Spectroscopy. Evid Based Complement Alternat Med 2011, Article ID 692798, doi:10.1093/ecam/nep036, 2011
  • Zausner C, Lassnig H, Endler PC, Scherer W, Haidvogl M, Frass M, Kastberger G, Lüdtke R: Die Wirkung von "homöopathisch" zubereitetem Thyroxin auf die Metamorphose von Hochlandamphibien. Ergebnisse einer multizentrischen Kontrollstudie. Perfusion 2002;17:268-7