Solution for injection with 20 mg folic acid (i.v., i.m.) For folic acid deficiency
For treating folic acid deficiency in dialysis patients when oral administration is not possible and when the standard dose does not have a sufficient effect.
Folic acid belongs to the group of B vitamins and it is involved in many metabolic processes, especially protein metabolism and metabolism of DNA (genetic material).
It is difficult to get enough folic acid from food because it is primarily found in vegetables and many people eat too few vegetables. In addition, a considerable percentage of the folic acid is destroyed by heat and light during food preparation.
Folic acid deficiency can be caused by:
• regular dialysis treatment
• drug treatment for cancer
• taking certain medicinal products, e.g., the Pill
• diet low in vegetables, e.g., in cases of increased alcohol consumption
• chronic diarrhea
Risks: There is a relationship between folic acid and:
• cardiovascular disease
• hearing disorders
• a decline in mental performance
Folic acid deficiency can be manifested by:
• an increase in homocysteine in the blood
• mucosal changes in the oral cavity
• gastrointestinal disorders with diarrhea
• changes to red blood cells (macrocytic anemia)
Important: Do not use doses higher than 5 mg per day during pregnancy and breast-feeding.
Sodium chloride, sodium hydroxide solution, water for injection.
|Dosage||Individually inject one-half to one ampoule 1 to 3 times a week intramuscularly or intravenously|
Treatment of folic acid deficiency in dialysis patients when oral folic acid supplementation is not possible and when a standard dose does not have a sufficient effect.
Folic acid is contraindicated in megaloblastic anemia due to isolated vitamin B12 deficiency. In cases of megaloblastic anemia of unknown etiology, tests should be done before the start of treatment to see if there is folic acid deficiency.
In rare, isolated cases allergic reactions including pruritis, rash, difficulty breathing and shock may occur. Following high doses, susceptibility to seizures increases with concomitant treatment with anti-epileptics. Furthermore, in rare cases following high doses gastrointestinal tract problems, nightmares, excitation and depression have been observed.
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